By successfully developing nanowell array (NWA) structures, it has become possible to develop nanobiomedical sensors for early diagnosis of diseases in humans and animals as well as environmental diagnostics. These nanobiomedical sensors, when applied to the electrochemical detection of DNA, proteins, and aptamers, have been experimentally shown to improve the limit of detection by approximately 150 times compared to existing detection methods.
Nanowell electrodes can reduce background noise,
enabling highly sensitive measurement of biomolecules.
When applying nanowell arrays to electrochemical nano-biosensors,
the limit of detection for the ovarian cancer marker STIP-1
is increased by 100 times compared to conventional methods.
H.Y. Lee et,al, Journal of Biotechnology, 168, 584-588 (2013)
“Single microfluidic electrochemical sensorsystem for simultaneous multi-pulmonary hypertension biomarker analyses”,
G.H.Lee, J.K.Lee, H.Y.Lee, et al., Scientific Reports, 7:7545 (2017)