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Nanowell Array based Nanobiomedical Device
for Leading a Better Life


나노-바이오 센서에는 20mm의 지름 내에 100nm X 500nm 크기, 직사각형 모양의 나노웰이 200 X 200개 배열되어 있습니다. 이를 통하여 혈액, 소변, 땀 등의 샘플 한 방울로부터 수치화 된 질환 정보를 얻을 수 있게 됩니다.

분자수준의 나노-바이오 센서

가정, 사무실 또는 가까운 곳 어디에서나 가능한 정확하고 신뢰도 높은 건강진단기술


휴대용 및 디지털 진단

나노의학 진단기기에서의 가장 중요한 과제 중 하나는 가정, 사무실 및 어느 곳에서나 정확하고 신뢰할 수 있는 건강 진단을 수행하는 것입니다. 이러한 목표를 달성하기 위해서는 혈액, 소변, 땀과 같은 소량의 샘플로부터 건강 정보를 디지털화 할 수 있는 새로운 의료 시스템이 필요합니다.


4S

이러한 시스템의 작동을 위해서는 네 가지 기능을 갖춘 다양한 나노-바이오 센서를 개발해야 하는데, 이 네 가지란 민감도, 선택성, 특이성과 고속 분석을 위한 높은 S / N 비율을 말합니다.

• 높은 신호대잡음비(High Signal-to-noise)
• 높은 선택성(High Selectivity)
• 높은 특이성(High Specificity)
• 빠른 속도(High Speed)


나노 규모의 예술적 결합

나노-바이오 센서의 이러한 성능은 나노 크기의 표면 또는 나노 물질의 조합을 통해 향상 되도록 설계 되었습니다.

특허

1. H.Y.Lee, “Nanomedical Sensor using  Nanowell Array Technology”, United States: Patent  Application Publications : US 2017/0219554

2. H.Y.Lee, “Protein chip and Biosensor using Nanowell Array Electrode”, Japanese Patent: #4497903 (2010.4.23)

기본개념
제한된 나노크기 공간에서 개별 분자의 반응을 제어한다
나노웰 어레이
Nanowell Arrays (NWA)

나노크기의 웰 안 지정된 위치에 생체분자들이 반응에 의해 고정됨

고감도, 고선택성, 고특이성을 갖는
나노-바이오 센서를 이용해 나노웰 안에 고정된 생체분자를 분석

H.Y.Lee et.al JACS (2005), Langmuir (2005), Lab on a chip (2006), Appl.Phys.Lett. (2006), Advanced Materials (2008)–The Highlight, Small (2008)

H.Y.Lee et.al.Japanese Patents  3972096 (2008); 4324707 (2009); 4497903 (2009)

HeaYeon Lee, Ph.D.
Chief Executive Officer

CEO, also CEO of Mara Nanotech Inc. New York since 2016. 

She has over 27 years of experience in the researches of chemistry, material science, semiconductor process and the development of nanobiotechnology based electrochemical diagnosis system.

Jeongwoo Choi, Ph.D. D.Eng. DBA.
Auditor Director

Auditor Director of Mara Nanotech Korea Inc. 

He has over 35 years of experience in the researches of nanobiochip and technology management. Currently a professor in Sogang University and CEO of IBT.

진단 키트용 나노웰 어레이 전극 개발

 NWA (2003)
1st (2011)
2nd (2014)
3rd (2017)
Microwell (2018)
image

Channel

2 channel

5 channel

8 channel

ONCHIP

Well size (diameter)

400 nm

50 nm

240 nm

700 μm

Space ratio

1:1

1:1

1:1

1:1

Number of well

2,500 x 5,000

200 x 200

2,500 x 5,000


Single well area

0.1256 µm2

0.0019625 µm2

0.07065 µm2


Total well area(real)

1.57 mm2

78.5 µm2

0.88 mm2


Manufacturing

57 ea on 8’’ wafer

112 ea on 8’’ wafer

55 ea on 8’’ wafer

55 ea on 8’’ wafer

Cost (8’’ wafer) 





Cost (1ea)





Cost (1 channel)






We have worked on digital nanobiomedical sensor system using electrochemical analysis and nanocosmeceudical with nanotechnology, nanobioscience, chemistry, material science and molecular engineering. Our company goal is to make nano-bio-diagnostic kits/system using nanowell array technology for health monitoring and nanocosmeceutical for skin health care. It is applicable in clinical medicine, skin healthcare, pharmacology, environmental industry.


Note that most hot issues in nanobiomedical technology, such as single biomolecule sensing devices, are still unsettled. I believe that a key solution to those issues could come from a nanoscale well array (NWA), which I have already proposed. Over the past 15 years, I have successfully fabricated a NWA structure using various nanofabrication methods and demonstrated that it can be used to fabricate a new nano-biosensor with ultra-high sensitivity and good reproducibility.


The geometry permits only one (or a few biomolecules) to enter and become attached to a nanosized substrate. When this array is applied to highly sensitive electrochemical DNA detection, a 150-orders-of-magnitude enhancement in sensitivity is obtained. This NWA system can be applied to numerous other integrated digital biomedical sensors. I have published several papers in important journals, and I have also been invited to several international conferences to give invited presentations. Most of these research results were generated from ideas I proposed myself.

Mara Nanotech Korea, Inc., South Korea

Mara Nanotech New York, Inc., USA


Visiting Scholar, Bouve College of Health Sciences, Northeastern University, Boston, MA

Adjunct Professor, College of Human Ecology,
Chungnam Nat'l University, South Korea


160 Convent Ave., Steinman Hall, RM B20,
New York, NY 10031-9101, US
TEL 781-999-2285
Email h.lee@mara-nanotech.com

HeaYeon Lee is a President/CEO in Mara Nanotech New York, Inc. and a Visiting Professor, Department of Pharmaceutical Sciences, Bouve College of Health Sciences, Northeastern University, Boston, MA.

She received her BS (1987) and MS degrees (1990) in Chemistry from Pukyong National University, South Korea and her Ph.D. degree (1995) in Chemistry from Osaka University, Japan. After finishing advanced degrees in nanofabrication and characterization technologies, she has been working on developing new nanobioelectronic devices and nanobiosensors. She was a Designated Professor at the Institute of Scientific and Industrial Research, Osaka University, and Research Associate Professor of Mechanical and Industrial Engineering at Northeastern University, Boston, USA. Her research work has been contributing to accelerating cutting-edge research in the emerging bio-nanoscience area.